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It commonly involves the lower limbs, but may involve any muscle. once within the body, agents that aremetabolized and excreted at a slower rate than absorbed accu-mulate in the target organ or tissue once within the body, agents that aremetabolized and excreted at a slower rate than absorbed accu-mulate in the target organ or tissue. These effects are not neces-sarily mutually exclusive; it is possible that this occurs through both p53-dependentand -independent mechanisms.
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